Table 1.

The relationships among rs1649942, miRNAs, mRNAs, and cellular sensitivity to platinum agents in the HapMap CEU discovery samples

rs1649942 association with platinum IC50P valuemiRNAassociation with platinum IC50P valueP
CarboplatinCisplatinmiRNArs1649942-miR association P valueCarboplatinCisplatinGeners1649942-geneGene-carboplatinGene-cisplatinmiRNA-gene
1E-57E-5miR-193b*3.4E-37.3E-31.6E-2CRIM13E-51.0E-49.8E-42.8E-5
IFIT21E-41.8E-27.6E-36.3E-5
OAS11E-53.7E-24.3E-25.2E-5
CCR65E-53.3E-22.0E-23.1E-4
3.5E-41.5E-4
CYP2R11E-43.3E-42.5E-32.0E-2
1E-42.2E-51.9E-32.7E-3
KYNU9E-69.3E-42.7E-44.8E-3
RAPGEF52E-62.0E-24.6E-21.0E-2
SLC2A52E-56.1E-31.5E-36.6E-3
USP129E-55.1E-44.2E-41.3E-3
ZHX127E-51.2E-56.2E-52.0E-2
miR-320a4.5E-21.0E-23.7E-2GRAMD1B1E-44.7E-44.4E-33.5E-5
KCNMA17E-52.4E-23.4E-29.1E-5
PSTPIP22E-51.6E-47.1E-41.9E-3
miR-4246.7E-32.4E-22.7E-2GRAMD1B1E-44.7E-44.4E-35.9E-3
KCNMA17E-52.4E-23.4E-29.8E-3
PSTPIP22E-51.6E-47.1E-42.0E-2
SHFM3P12E-62.8E-31.2E-24.0E-2
4E-5

NOTE: Bold, miRNA and gene pairs meet negative correlation and P < 10−4 cutoff and were evaluated in replication samples.