Table 3.

KU-0060648 tumor and plasma concentration following a 12.5 mg/kg i.v. dose in mice bearing subcutaneous MCF7 or SW620 human xenografts

MCF7SW620
Plasma, μmol/LTumor, μmol/LPlasma, μmol/LTumor, μmol/L
60 min1.0 ± 0.67.0 ± 3.82.1 ± 0.54.9 ± 0.3
240 min0.8 ± 0.54.7 ± 1.10.7 ± 0.22.9 ± 0.4

NOTE: Data are the mean ± SD of values obtained from 3 mice per time point.