Table 2.

Plasma PK parameters following administration of KU-0060648 by the i.v., p.o., or i.p route in female Balb/C mice

KU-0060648 (10 mg/kg)
Dose and routei.vp.oi.p
Cmax, μg/mL1.90.90.9
Tmax, min512030
AUCinf, μg/mL*min242287189
T1/2 (min)102142106
CL (ml/kg/min)413554
Bioavailability (%)11978

NOTE: Data are calculated from mean values obtained at 5,10,15, 30, 60, 90, 120, 180, 240, and 360 minutes after administration from 3 mice per time point.

Abbreviations: Cmax, concentration maximum; Tmax, time of Cmax; AUC, area under the curve; T½, elimination half-life; CL, clearance.