Plasma PK parameters following administration of KU-0060648 by the i.v., p.o., or i.p route in female Balb/C mice
KU-0060648 (10 mg/kg) | |||
---|---|---|---|
Dose and route | i.v | p.o | i.p |
Cmax, μg/mL | 1.9 | 0.9 | 0.9 |
Tmax, min | 5 | 120 | 30 |
AUCinf, μg/mL*min | 242 | 287 | 189 |
T1/2 (min) | 102 | 142 | 106 |
CL (ml/kg/min) | 41 | 35 | 54 |
Bioavailability (%) | 119 | 78 |
NOTE: Data are calculated from mean values obtained at 5,10,15, 30, 60, 90, 120, 180, 240, and 360 minutes after administration from 3 mice per time point.
Abbreviations: Cmax, concentration maximum; Tmax, time of Cmax; AUC, area under the curve; T½, elimination half-life; CL, clearance.