Table 2.

Plasma PK parameters following administration of KU-0060648 by the i.v., p.o., or i.p route in female Balb/C mice

	KU-0060648 (10 mg/kg)
Dose and route	i.v	p.o	i.p
C_max, μg/mL	1.9	0.9	0.9
T_max, min	5	120	30
AUC_inf, μg/mL*min	242	287	189
T_1/2 (min)	102	142	106
CL (ml/kg/min)	41	35	54
Bioavailability (%)		119	78

NOTE: Data are calculated from mean values obtained at 5,10,15, 30, 60, 90, 120, 180, 240, and 360 minutes after administration from 3 mice per time point.

Abbreviations: C_max, concentration maximum; T_max, time of C_max; AUC, area under the curve; T_½, elimination half-life; CL, clearance.