Table 1.

Ovarian cancer cell line response to Smo antagonists, alone and in combination with paclitaxel

Mean IC50, μmol/LMean paclitaxel IC50, nmol/L
Cell lineCyclopamineLDE225Controlw/Cyclopamine (5 μmol/L)w/LDE225 (5 μmol/L)P
A2780ip27.51241.52.6NS
A2780cp20107.5301.31.5<0.05
SKOV3ip11424635.5NS
SKOV3TRip2191240015120<0.05
HeyA8121874.26.5NS
HeyA8MDR13865050115<0.05

Abbreviation: NS, not significant.