Table 2.

Cellular IC50 as well as fold difference between the parental and MEK-R line

Cell lineIC50 MEKi-1 (μmol/L)IC50 MEKi-2 (μmol/L)IC50 ERKi (μmol/L)
COLO206F parental0.010.080.3
COLO206F-AR MEK-R1.5101.25
IC50 shift MEK-R/parental150×125×4.17×