Table 1.

Agents targeting eIF4F

Primary targetCompoundCompound classTested cancerStudyReference
eIF4E phosphorylationCercosporamideSmall organicXenograft melanomaPreclinical(47)
eIF4E synthesis4E-ASO LY2275796OligonucleotideMultiple human cancersPhase I(30, 54)
eIF4E-cap interaction4Ei-1Small organicBreast carcinoma cell linesLaboratory(60–62)
eIF4E–eIF4G interaction4EGI-1Small organicMultiple human cancer cell linesLaboratory(31)
[DLys6]GnRH-4EBP1-WTOligopeptideXenograft ovarianLaboratory(32)
4E1RCatSmall organicMouse lymphomaLaboratory(50)
eIF4A activityPateamine ASmall organicXenograft melanomaLaboratory(51, 52)
SilvestrolSmall organicMouse lymphomaLaboratory(29, 50, 53)