Table 3.

Comparison of PIK3CA helical (exon 9) and kinase (exon 20) domain mutations

CharacteristicHelical N (%)Kinase N (%)P-value
Stage
 Early (IA–IIIA)5 (22)4 (18)1.0
 Advanced (IIIB/IV)7 (30)7 (30)
Comutation
 Yes9 (39)7 (30)0.67
 No3 (13)4 (18)
Smoking
 Never1 (4)7 (30)0.009
 Former/current11 (48)4 (18)