Table 1.

Eight cells lines summarizing type of sarcoma, p53 mutational status, and IC50 doses for MK1775 in each of the 9 cell lines calculated from the cell viability assay

MK1775 IC50
Cell linep53Tumor typeIC50
MG63NullOsteosarcoma300.2-E9
U2OSWTOsteosarcoma546 2-E9
SW872MutLiposarcoma321.8-E9
A673MutEwing sarcoma517.7-E9
SKUTMutLeiomyosarcoma430.5-E9
MNNGNullOsteosarcoma338.1-E9
HT1080WTFibrosarcoma168.7-E9
SKESMutEwing sarcoma112.2-E9

NOTE: Data shown as mean ± SD n = 3.

Abbreviations: Mut, mutant; WT, wild-type.