Table 1.

Enzymatic activities in tissues of WT and UPase−/− mice (nmol/mg/h)

UPaseTPaseUKOPRTaseDPD
WTUPase−/−WTUPase−/−WTUPase−/−WTUPase−/−WTUPase−/−
Liver5.6 ± 1.51.3 ± 0.325.9 ±6.226.7 ± 7.30.9 ± 0.31.6 ± 0.3a2.3 ±0.42.1 ± 0.52.0 ± 0.32.0 ± 0.4
Small intestine696.8 ± 80.0ND1.9 ± 0.52.0 ± 0.50.4 ± 0.20.5 ± 0.20.8 ±0.30.7 ± 0.4
Colon 3828.5 ± 4.727.9 ± 5.30.2 ± 0.10.2 ± 0.16.6 ± 1.56.8 ± 1.32.5 ±0.22.5 ± 0.3
  • Abbreviations: TPase, thymidine phosphorylase; UK, uridine kinase; OPRTase, orotate phosphoribosyltransferase. +/+, UPase WT; −/−, UPase knockout; ND, not detectable.

  • a, P < 0.05 compared with WT mice.