Table 2.

Potency of selected agents for various tyrosine kinase receptors

IC50 (nM)a
TargetSunitinibSorafenibPazopanibAxitinib
VEGFR-12101.2
VEGFR-21090300.25
VEGFR-31720470.29
PDGFR-β857841.7
EGFR88058
c-KIT1068741.6
FGF-1R88058014230
FLT-31458
Raf-16
CSF-1R100

NOTE: Data from refs. 69–71.

Abbreviations: FGF, fibroblast growth factor.

  • aIC50 represents the concentration of a drug that is required to achieve 50% inhibition of the enzyme in a biochemical assay.