Schedule of the treatments and window imaging on days 1, 3, and 5 before and after treatment with vehicle and olaparib with or without radiation
Day | ||||||
---|---|---|---|---|---|---|
Group | 0 | 1a | 2 | 3a | 4 | 5a |
Vehicle | Vehicle | Vehicle | Vehicle | Vehicle | Vehicle | |
Olaparib | Olaparib | Olaparib | Olaparib | Olaparib | Olaparib | |
Vehicle + 5 × 2 Gy | 2 Gy | Vehicle (2 Gy) | Vehicle (2 Gy) | Vehicle (2 Gy) | Vehicle (2 Gy) | Vehicle |
Olaparib + 5 × 2 Gy | 2 Gy | Olaparib (2 Gy) | Olaparib (2 Gy) | Olaparib (2 Gy) | Olaparib (2 Gy) | Olaparib |
NOTE: In the combination treatments, the mice were irradiated with 2 Gy on day 0, and vehicle and olaparib were given 24 hours later on day 1 at the time of imaging. Once imaging was finished, the mice were given the next fraction (2 Gy) of radiation.
↵aReal-time IVM imaging.