Table 1.

Schedule of the treatments and window imaging on days 1, 3, and 5 before and after treatment with vehicle and olaparib with or without radiation

Day
Group01a23a45a
VehicleVehicleVehicleVehicleVehicleVehicle
OlaparibOlaparibOlaparibOlaparibOlaparibOlaparib
Vehicle + 5 × 2 Gy2 GyVehicle (2 Gy)Vehicle (2 Gy)Vehicle (2 Gy)Vehicle (2 Gy)Vehicle
Olaparib + 5 × 2 Gy2 GyOlaparib (2 Gy)Olaparib (2 Gy)Olaparib (2 Gy)Olaparib (2 Gy)Olaparib

NOTE: In the combination treatments, the mice were irradiated with 2 Gy on day 0, and vehicle and olaparib were given 24 hours later on day 1 at the time of imaging. Once imaging was finished, the mice were given the next fraction (2 Gy) of radiation.

  • aReal-time IVM imaging.