Table 2.

qRT-PCR–based screens reveal 18 compounds inhibiting the expression of MELK, ASPM, TOP2A, and FOXM1b

LibraryCompound IDMELKASPMTOP2AFOXM1B
ChemBridge#5560509−2.1−3.5−3.2−1.5
ChemBridge#5256360−2.6−1.4−4.0−2.0
PrestwickCamptothecine (S,+)−2.3−1.5−0.2−0.5
ChemBridge#5402594−0.2−1.8−2.4−0.5
ChemBridge#5551547−0.8−1.8−2.00.0
ChemBridge#5349968−0.7−0.2−3.2−4.3
ChemBridge5356272−0.5−1.0−2.1−2.3
ChemBridge#5354001−0.7−1.1−1.7−2.6
ChemBridge#5194403−0.1−0.51.0−3.6
ChemBridge#5212518−0.1−0.3−1.2−2.2
ChemBridge#5316908−0.6−0.7−1.1−1.6
BIOMOLRo 31-8220−2.70.80.31.2
BIOMOLC8 Ceramine−1.90.2−0.7−0.4
BIOMOL6-Formylindolo[3,2-B]Carbazole−1.70.60.6−1.0
PrestwickChelidonine monohydrate (+)−0.2−1.9−1.20.1
PrestwickMethiazole−1.1−1.5−0.50.1
ChemBridge#52174971.71.50.1−1.8
ChemBridge#5241816−0.3−0.7−1.4−1.7

NOTE: Degree of gene expression downregulation is expressed as Z scores; Z < −1.5 were considered hits (bold).