Table 1.

Physicochemical properties and pan-HDAC inhibition activities

CompoundCarbon linker (n)HDAC IC50 [nmol/L]PSAMWCLogPMV(Å)3Excitation (nm)Emission (nm)
11287213.7365.451.191,037.4320500
22125218.4379.481.721,067.5320500
33116218.7393.502.251,104.2320500
44208216.3407.532.781,194.5320500
SAHA80180.1264.320.99868.7

NOTE: Compound structures are shown in Fig. 1.

Abbreviations: PSA, polar surface area; MW, molecular weight; CLogP, calculated log of the partition coefficient; MV, molecular volume; Excitation, excitation wavelength; Emission, emission wavelength.