Table 1.

In vitro assays were conducted for the indicated kinases

KinaseCompound 1 (IC50), nmol/LCompound 2 (IC50), nmol/LBrivanib (IC50), nmol/LTKI-258 (IC50), nmol/LZD6474 (IC50), nmol/L
FGFR331552182,200
FGFR1137815131,300
FGFR233663221260
FGFR43494>1,0004709,300
VEGFR1134409.05375
VEGFR368320ND42220
VEGFR21003804.25.412
PDGFRβ2902,500ND151,500
Flt38260NDNDND
EGFR>10,000>10,000ND>10,00030
ErbB2>10,000>10,000NDND2,900

NOTE: IC50 was calculated using Prism software and expressed as mean of at least 2 independent experiments conducted in duplicate.

Abbreviation: ND, not determined.