Table 2.

HDAC isomer inhibition activity

HDAC isomer IC50 (╬╝mol/L)a
Compound123456781011
20.951.381.120.330.400.132.563.980.420.48
31.297.404.890.670.370.086.402.580.420.52
SAHA0.220.561.790.640.130.0270.992.740.110.082
  • aHDAC class I (1, 2, 3, and 8); class II (4, 5, 6, 7, 9, and 10); class IV (11).