Table 3.

Effect of compound 2 on cell cycle distributions

CompoundCell lineCell cycle distribution (%)
G1SG2
ControlLNCaP72.508.958.55
2LNCaP85.239.185.59
ControlPC347.2921.1531.56
2PC364.3519.9115.74
SAHAPC372.2814.3313.39
ControlA54979.279.8110.93
2A54982.632.0315.34
SAHAA54988.582.009.41
ControlMCF-762.0329.738.24
2MCF-775.7612.9411.30
SAHAMCF-777.436.6815.89

NOTE: GI50s of SAHA at 1.04 μmol/L for PC3 and the compound 2 at 1.54 μmol/L for PC3 and 1.3 μmol/L for LNCaP were used. A549 cells were treated with 10 μmol/L of compound 2 and SAHA. No obvious change at 1 μmol/L concentration was observed. MCF-7 cells were treated with 1 μmol/L of compound 2 and SAHA.