Table 2.

Apoptosis induction according to Annexin V staining in MCF7 cells treated with pyriplatin, cisplatin, or oxaliplatin for 24 hours followed by incubation in drug-free medium for 24, 48, or 72 hours

ControlPyriplatin (25 μmol/L)Cisplatin(2 μmol/L)Oxaliplatin (0.4 μmol/L)
24hT9.6316.8422.8818.02
24hR21.4051.7048.7021.94
48hR28.5332.5729.7235.42
72hR22.2616.6613.9816.76

NOTE: All values are expressed in percentage. According to the experimental schedule, data are expressed as percentage of apoptotic cells. Corresponding data for HCT-116 cells are reported in the supporting information.

Abbreviations: T, immediately after drug exposure; R, after wash-out.