Table 4.

Paclitaxel PK parameters in plasma

ParameterDose level 1Dose level 2Dose level 3Dose level 4
Cmax (μg/mL)1.00 ± 0.521.25 ± 0.901.63 ± 0.492.04 ± 0.73
Tmax (h)1.01.01.01.0
AUC (last; μg × h/Ml)1.14 ± 0.451.43 ± 0.901.70 ± 0.372.29 ± 0.74
Clearance (L/h)33.98 ± 7.6137.50 ± 17.0631.90 ± 7.2127.16 ± 10.55
T½ (h)1.75 ± 1.450.69 ± 0.201.96a1.83 ± 0.86
Vz (L/m2)95.15 ± 101.0234.50 ± 28.7885.59a64.31 ± 37.93
  • aSD was not calculated because of the small number (<3) of data points.