Table 1.

Four-month survival analysis of Ntv-a mice with Shh + HGF–induced medulloblastomas

Therapeutic agentDosing regimenNo. of mice analyzedMedian survival (d)P
5G82.5 mg/kg i.p. twice weekly6023
L2G72.5 mg/kg i.p. twice weekly581110.03
Cyclopamine + 5G810 mg/kg i.p. every other day + 5G860620.04
L2G7 + cyclopamineSee above regimens59470.8
5E15.0 mg/kg i.p. twice weekly34>1020.04

NOTE: P values were derived from log-rank tests comparing cumulative survival of each test group with 5G8 control. The P value for the cyclopamine group was calculated over a 90-d observation period.