Table 2.

Cytotoxicity of NXD30001 and 17-AAG in mouse and human GBM cultures as determined by cell proliferation assays

GBM culturesNXD3000117-AAG
IC50 (nmol/L)IC50 (nmol/L)
Mouse
    241431.7 ± 4.9205.1 ± 13.1
    4654.3 ± 12.591.9 ± 1.4
    6973.4 ± 2.591 ± 4.3
    4273.8 ± 0.7165.5 ± 24.9
    273677.6 ± 2.8381 ± 24.1
    GBM-178.3 ± 8.3207.5 ± 9.6
    4180.2 ± 5.9100.2 ± 5.0
    GBM-2110.8 ± 9.41,096.4 ± 118.6
    2000115.4 ± 9.4344.8 ± 75.5
    2227134.3 ± 7.7712 ± 54.4
    2231146.1 ± 3.7737.3 ± 72.0
    2415251.1 ± 57.7328.8 ± 50.1
    102360.5 ± 21.6626.2 ± 6.0
    103575.6 ± 14.8793.5 ± 28.7
Human
    GBM1560.7 ± 0.5110.4 ± 13.4
    GBM4386.3 ± 0.286.9 ± 2.3
    GBM39111.6 ± 1.0241.7 ± 1.2
    GBM59232 ± 13.2211.2 ± 11.0
    GBM61,217.5 ± 35.1531.7 ± 5.0
    GBM122,334 ± 60.02,575.9 ± 166.5
    GBM225,261.6 ± 152.24,668.2 ± 148.0
    GBM85,691.3 ± 449.68,010.8 ± 542.6

NOTE: Results are presented as the mean ± SD of three independent experiments.