Table 3.

Mean pharmacokinetic parameters of PHA-848125 in preclinical species

SpeciesGendert1/2 (h)CL (L/h/kg)Vss (L/kg)F (%)
MouseM1.91.83.580
RatM3.41.97.566
DogM/F6.71.91259
MonkeyM/F4.11.45.330