Table 1.

Kinase inhibition profile of PHA-848125

KinaseIC50 (nmol/L)
CDK2/cyA45
CDK/cyH150
CDK4/cyD160
CDK5/p25265
CDK2/cyE363
CDK1/cyB398
TRKA53
85*
TRKC134*
TRKB745*
LCK209
ABL478
PDGFR579
KIT668

NOTE: IC50, the concentration of PHA-848125 inducing 50% inhibition of kinase activity.

  • *Obtained from Invitrogen SelectScreen Kinase Profiling Service.