Table 1.

Combination index

Bortezomib (nmol/L)Degrasyn (μmol/L)
11.52
Mino
21.170.940.81
41.190.910.73
61.120.790.61
80.910.480.32
100.680.250.32
Z-138
21.281.070.59
41.110.910.49
61.090.740.44
81.010.620.41
100.950.610.33
DB
21.211.090.76
41.181.030.68
61.190.940.63
81.110.970.51
100.910.710.28
JMP-1
21.211.070.97
41.181.050.86
61.150.910.78
81.060.890.56
100.980.750.45

NOTE: Combination index <0.2, synergism; 0.2–0.3 very strong; 0.3–0.7, moderate; 0.7–0.85 slight; 0.85–1 synergy; >1.0 no synergy. The drug combination index for bortezomib and degrasyn (CI) was calculated by using the CalcuSyn software program. A combination index value of 1 indicated an additive effect of the two drugs. Combination index values of <1 indicated synergy; the lower the value, the stronger the synergy. In contrast, combination index values of >1 indicated antagonism.