Table 2.

In vitro protection from APO866 by nicotinic acid

Cell lineAPO866 LD50 in CA (nmol/L)NA rescue effect
ML-24,8 ± 1,0+ (>500)
HCT-1169,0 ± 3,2+ (>500)
A43111,6 ± 5,5+ (>500)
NYH1,8 ± 0,2− (1,5 ± 0,1)
PC-34,8 ± 3,0− (5,5 ± 1,4)
A27803,3 ± 1,7− (5,34 ± 0,2)

NOTE: Rescue effect defined as ≥40-fold increase of LD50 to APO866 treatment. No rescue effect defined as <2-fold increase in LD50. LD50 values for combination treatment with nicotinic acid are shown in nmol/L in parentheses. All LD50 values are displayed with SDs.

Abbreviations: NA, nicotinic acid; CA, clonogenic assay.