Table 1.

US Food and Drug Administration–approved anticancer agents: activity in the NCI60 panel

NameNSC no.Potency in μmol/L
Mean GI50Mean TGIMean LC50
Signaling agents
    Bortezomib6812390.000510.00633.6
    Dasatinib7325170.338.951
    Erlotinib7187815.559>90
    Everolimus7335040.0951456
    Gefitinib7150553.21949
    Imatinib743414154381
    Lapatinib7457502.92061
    Nilotinib7475992.91349
    Sorafenib7479711.9630
    Sunitinib7506902.29.631
    Temsirolimus6838640.03851>100
DNA damaging agents
    Actinomycin D30530.00140.0580.52
    BCNU (Carmustine)40996265170330
    Bendamustine13878360>100>100
    Bleomycin1250661.31223
    Busulfan750210970>1,000
    Carboplatin241240100>220>240
    CCNU (Lomustine)7903736120310
    Chlorambucil308852260580
    Cisplatin1198751.432>420
    Cyclophosphamide26271210>250>250
    Dacarbazine4538855>800>1,000
    Hexamethylmelamine13875140>150>150
    Ifosfamide109724320>440>475
    Melphalan880627110210
    Methoxsalen4592396>100>100
    Mitomycin C269800.716.618
    Mithramycin245590.0130.65200
    Nitrogen mustard7622.819100
    Oxaliplatin2660462.852>90
    Pipobroman2515464210370
    Procarbazine77213440>470>500
    Quinacrine142291.75.219
    Streptozotocin85998570>650>700
    Temozolomide36285697>100>100
    ThioTEPA639670400770
    Triethylenemelamine97068.73375
    Uracil mustard3446224160>410
Tubulin-directed agents
    Docetaxel6285030.01412>85
    Ixabepilone747973<0.00001<0.00001<0.00001
    Paclitaxel1259730.0253.975
    Vinblastine498420.000010.2832
    Vincristine675740.004513250
    Vinorelbine6082100.0184.252
Anthracyclines/Topoisomerase poisons
    Daunorubicin821510.0681.110
    Doxorubicin1231270.0972.113
    Epirubicin2569420.22.727
    Etoposide1415406.650420
    Idarubicin2564390.0380.253.8
    Irinotecan6163481458>100
    Mitoxantrone3017390.0590.887.8
    Teniposide1228190.414.620
    Topotecan6096990.0312.543
    Valrubicin2461310.49641
Antimetabolites/Nucleosides
    5-azacytidine1028160.958.7350
    5-fluorouracil19893181,600>2,400
    6-Mercaptopurine7557.4540>740
    Allopurinol13904304,200>5,000
    Calcium leucovorin359093>100>100
    Capecitabine71280780>10,000>10,000
    Cladribine1050145.155>100
    Clofarabine6068690.422586
    Cytarabine638788.2340>500
    Decitabine12771637260350
    Floxuridine276400.39755>2,400
    Fludarabine31288743410>1,100
    Gemcitabine6133270.241878
    Hydroxyurea32065560>2,000>2,400
    Methotrexate7400.3210>250
    Nelarabine6866732,700>5,000>5,000
    Pemetrexed69803711>100>100
    Pentostatin218321440>480>500
    Thioguanine7521.347210
Hormonal agents
    Anastrozole7193442,500>9,000>10,000
    Delta-1-testololactone23759420>500>500
    Dimethyltestosterone8853627>80>100
    Dromostanolone propionate121982986>100
    Estramustine7022944285>100
    Ethinyl estradiol109732578>100
    Exemestane7135632568>100
    Fulvestrant71927662>100>100
    Letrozole7193453,400>5,000>5,000
    Megestrol acetate7142364>100>100
    Mitotane38721143773
    Naldrolone23162184583
    Raloxifene7479748.12871
    Tamoxifen1809734.61823
    Toremifene613680132959
Other
    Amifostine296961540>700>750
    Aminolevulinic acid18509>100>100>100
    Arsenic trioxide7063634.5>10>13
    Celecoxib719627173463
    Dexrazoxane169780160970>2,000
    Imiquimod36910043>100>100
    Lenalidomide747972>100>100>100
    Levamisole177023>100>100>100
    Mesna11389198>100>100
    Nelfinavir7471675.22068
    Romidepsin6301760.000250.00810.038
    Thalidomide66847>100>100>100
    Tretinoin (ATRA)1227585178>100
    Vorinostat7018520.941770
    Zoledronic acid72151764>100>100