Table 1.

Clinical characteristics of the chronic lymphocytic leukemia patients

Patient no.Age (y)SexRai stageLeukocytosis, ×103/μLAbsolute lymphocytosis, ×103/μLPrior treatment statusZAP-70 status*IgVH statusCD38 statusCytogenetics
170FI204.1142.9UntreatedUnmutated+del 11q
271MIII59.9948TreatedNAMutateddel 13q
377MI19.1713.7UntreatedNANA+NA
465FIII59.647.7Treated+NAdel 13q
581FIV51.0131.68TreatedMutated+NA
678FI32.0420.8TreatedNA+Trisomy 12; del 13q
780MIII33.927.12UntreatedNANANA
874MI27.7520.8UntreatedNANANA
965M020.6214.4Untreated+Unmutated+Trisomy 12
1065FIII24.0519.2TreatedNAUnmutated+del 13q
1178MIV235.2172.9TreatedNAMutatedNANA
1261MIV15.7213.77TreatedNA+del 13q14.3; del 17p13
1377FIII73.5451.48Untreated+Unmutated+NA
1475MI31.7719.1TreatedNANA
1567FIII39.2333.3Treated+NA+del 13q; del 17p
1646MI10.484.79Untreated+NANA
1771F019.4613.44Untreated+NANA
1859F019.4914.01UntreatedUnmutateddel 11q; del 13q
1959MI23.9616.8UntreatedNA+del 11q; del 13q
2049M016.327.65UntreatedUnmutated+del 11q; Trisomy 12
2172FI17.7410.29UntreatedMutated+Trisomy 12
2272MI41.3324.8UntreatedNA+NA
2366F08.045.05UntreatedMutateddel 13q
2457F010.246.24UntreatedMutatedNA
2571M012.957.5UntreatedNANA+NA
2670FIII12.239.8Treated+Unmutated+Normal
2779MIV26.6119.96Treated+MutatedNATrisomy 12
2865F011.136.9UntreatedMutateddel 13q
2975MI29.6320.3Untreated+NA+NA
3062MI11088UntreatedUnmutated+Normal
3170MIV17.313.57TreatedNANA
3246MIV4.721.44TreatedNANA+NA
  • *Sample with >20% of CLL cells expressing ZAP-70 is considered ZAP-70+.

  • IgVH gene with <98% homology with the corresponding germline gene is considered mutated.

  • Sample with >7% of CD38-positive CLL cells is considered CD38+.