Table 3.

A panel of human tumor cell lines were exposed to AT7867, the in-cell phosphorylated GSK3β ELISA was done, and the IC50 for phosphorylated Ser9 GSK3β signal was determined

Cell lineCancer typepSer9 GSK3β ELISA IC50 ± SEM (μmol/L)
MES-SAUterine2.31 ± 0.61
MDA-MB-468Breast4.45 ± 1.47
MCF-7Breast2.78 ± 1.34
U87MGGlioma2.08 ± 0.28
PC-3Prostate2.65 ± 0.79
DU145Prostate3.21 ± 0.28
HCT116Colon3.3 ± 0.46
HT29Colon3.09 ± 1.46