Table 2.

Concentration (ng/mL) of PKI-402 in serum and tumor following a single dose

Pharmacokinetic summaryng/mL
CompoundRouteDoseFormulation1 h4 h6 h8 h24 h
PKI-402i.v.50 mg/kgSaline/lactic acidSerum6,2281,215527549
Tumor8,3196,5763,2652,219
PKI-402i.v.100 mg/kgSaline/lactic acidSerum814132
Tumor2,8131,184

NOTE: PKI-402 accumulation in tumor tissue was observed at 4 to 8 h (50 mg/kg) and at 8 to 24 h (100 mg/kg).