Table 1.

Rapamycin and perifosine combination index (CI) values based on the Chou-Talalay method

CombinationRapamycin (nmol/L)Perifosine (μmol/L)CI
11250.165
215.00.468
352.50.386
455.00.468
5102.50.352
6105.00.446

NOTE: MM.1S cells were cultured at varying concentrations of rapamycin (1, 5, and 10 nmol/L) with perifosine (2.5 and 5 μmol/L) and cytotoxicity evaluated by MTT assay at 48 h. CIs were calculated based upon the isobologram generated using the Chou-Talalay method.