Table 4.

Altered gene expression in lipid metabolism pathways of H630-cTFT versus H630 cells and H630-4TFT versus H630 cells

Gene nameGene IDGene descriptionRatio*Gene functionChromosome
H630-cTFT cells
PLA2 G2ANM_000300Phospholipase A2 group IIA47.83Hydrolysis of fatty acids; lipid catabolism1p35
UGT1A6NM_001072UDP glucuronosyltransferase 1 family, polypeptide A66.45Metabolism2q37
PLA2G4ANM_024420Phospholipase A2, group IVA4.85Lipid catabolism, phospholipid catabolism1q25
HMGCS1NM_0021303-Hydroxy-3-methylglutaryl- CoA synthase 1 (soluble)3.48Acetyl-CoA metabolism, cholesterol biosynthesis, lipid metabolism5p14-p13
AKR1C3NM_003739Aldo-keto reductase family 12.83Cell proliferation, lipid and prostaglandin metabolism10p15-p14
FDFT1NM_004462Farnesyl-diphosphate farnesyltransferase 12.65Cholesterol and isoprenoid biosynthesis8p23.1-p22
ALDH9A1NM_000696Aldehyde dehydrogenase 9 family, member A12.44Hormone metabolism, oxidation reduction1q33.1
CPT1ANM_001876Carnitine palmitoyltransferase 1A0.22Lipid metabolism, fatty acid metabolism, fatty acid β-oxidation, transport11q13.1-q13.2
CYP2B6NM_000767Cytochrome P450, family 2, subfamily B, polypeptide 60.41Arachidonic acid metabolism, oxidation reduction9q13.2
OGTNM_003605O-linked N-acetylglucosamine (GlcNAc) transferase0.41Response to nutrients, signal transductionXq13
H630-4TFT cells
TPI1NM_000365Triosephosphate isomerase 12.60Fatty acid biosynthsis, glyceraldehyde-3-phosphate metabolic process, glycolysis, pentose-phosphate shunt12p13
LYPLA1NM_006330Lysophospholipase I2.17Fatty acid metabolism, lipid metabolism8q11.23
HSD17B8NM_014234Hydroxysteroid (17-β) dehydrogenase 82.30Androgen metabolism, estrogen biosynthesis, oxidation reduction6p21.3
EHHADHNM_001966Enoyl- CoA, hydratase2.27Fatty acid β-oxidation, fatty acid metabolism, lipid metabolism, oxidation reduction3q26.3-q28
DGKENM_003647Diacylglycerol kinase0.47Phospholipid biosynthesis, intracellular signaling cascade17q22
OGTNM_003605O-linked N-acetylglucosamine (GlcNAc) transferase0.41Response to nutrients, signal transductionXq13
  • *Genes that were upregulated or downregulated at least 2-fold were selected. Data are expressed as the ratio between mRNA levels of H630-cTFT or H630-4TFT compared to H630.