Table 2.

Antitumor activity of PHT-427

TumorVolume at start (mm3)Dose (mg/kg)ScheduleTumor growth rate (mm3)/10 dT/C %P
BxPC-3 pancreatic156ControlBID × 5 d228 ± 46
125BID × 5 d67 ± 3529.40.030
250BID × 5 d46 ± 5320.10.027
97ControlBID × 10 d279 ± 37
100BID × 10 d181 ± 5264.8NS
200BID × 10 d77 ± 4427.60.004
Panc-1 pancreatic200ControlBID × 10 d318 ± 53
200BID × 10 d308 ± 5997.1NS
MiaPaCa-2 pancreatic200ControlBID × 10 d318 ± 53
200BID × 10 d308 ± 5997.1NS
PC-3 prostate229ControlBID × 5 d780 ± 161
125BID × 5 d470 ± 12160.3NS
SKOV-3 ovarian192ControlBID × 10 d432 ± 59
250BID × 10 d122 ± 1628.30.001
A-549 NSCLC157ControlBID × 10 d413 ± 37
200BID × 10 d182 ± 4744.10.016
MCF-7 breast142ControlBID × 10 d410 ± 101
100BID × 10 d383 ± 13993.4NS
200BID × 10 d156 ± 3038.00.042

NOTE: There were eight female mice per group. Control mice received vehicle only (0.1 mL sesame seed oil). The growth rate of individual tumors was measured over the period of dosing, and the mean for each treatment group was compared with control using Student's t test to obtain P values. Values are the mean ± SE.

Abbreviations: T, mean growth rate of test (drug treated); C, mean growth rate of control tumor expressed as a percent; NS, not significantly different (P > 0.05). BID, twice a day.