Table 4.

Toxicity according to polymorphisms (number of patients)

PolymorphismSkin rash (0 vs 1+)PSkin rash (0–1 vs 2+)PDiarrhea (0 vs 1+)PDiarrhea (0–1 vs 2–3)P
EGFR (CA)n
    SS9 vs 180.1117 vs 100.1113 vs 130.9924 vs 21.00
    SS-LL32 vs 2848 vs 1239 vs 2055 vs 4
EGFR −191 C/A
    CC36 vs 360.2754 vs 180.9944 vs 260.5669 vs 1<0.01
    CA-AA5 vs 1011 vs 48 vs 710 vs 5
EGFR −216 G/T
    GG11 vs 190.1821 vs 100.3114 vs 160.0624 vs 6<0.01
    GT-TT30 vs 2744 vs 1238 vs 1755 vs 0
EGFR R497K
    GG-GA37 vs 380.8356 vs 180.9948 vs 260.1771 vs 30.02
    AA4 vs 78 vs 34 vs 67 vs 3
AKT1-SNP3
    CC-CT40 vs 420.3662 vs 200.6048 vs 320.6474 vs 60.99
    TT1 vs 43 vs 24 vs 15 vs 0
AKT1-SNP4
    GG-GA36 vs 440.4160 vs 200.9947 vs 320.4073 vs 60.99
    AA4 vs 25 vs 15 vs 16 vs 0

NOTE: Because no DNA was available for SNPs evaluation in 2 of the patients with data on toxicity, the statistical analyses were done in a total number of 87 and 85 patients for skin and gastrointestinal toxicity, respectively. The worst toxicity grade for each patient was reported.