The different dosing schedules of the efficacy studies shown under Fig. 2A and B are compared with regard to the total administered dose, TGI, and body weight loss
| Dosing Schedule | Dose | Total dose in 3 wk | TGI (day 21) | Max. body weight loss (study day) | Body weight loss (day 21) |
|---|---|---|---|---|---|
| Daily | 25 mg/kg | 525 mg/kg | 37%* | 9.1% (day 9) | 5.7% |
| Daily | 50 mg/kg | 1,050 mg/kg | 61%*** | 10.0% (day 17) | 7.7% |
| Daily | 75 mg/kg | 1,575 mg/kg | 76%*** | 8.6% (day 17) | 6.3% |
| Daily | 100 mg/kg | 2,100 mg/kg | 97%*** | 16.6% (day 19) | 15.5% |
| Twice a day | 37.5 mg/kg | 1,575 mg/kg | 84%*** | 14.7% (day 20) | 14.4% |
| Every other day | 125 mg/kg | 1,375 mg/kg | 81%*** | 6.8% (day 20 | 6.1% |
| 3d on-4d off | 150 mg/kg | 1,350 mg/kg | 82%*** | 14.7% (day 13) | 9.7% |