Table 3.

The pharmacokinetic parameters shown in the graph under Fig. 2A were calculated by a noncompartmental method using the WinNonlin 4.0 software. All data shown are averages derived from three individual mice

ParameterSB939SAHA
Cmax (ng/mL)2,632501
Tmax (h)0.170.50
T1/2 (h)2.440.75
AUC0-last (ng×h/L)1,836594
AUC0-∞ (ng×h/L)1,841619
F (%)348.3