Table 2.

Effects of SB939 and SAHA on cell proliferation of human cancer cell lines

Cell typeCell lineSB939 IC50 (μmol/L)SDn*SAHA IC50 (μmol/L)SDn*
Colon cancerColo2050.540.0682.140.5620
HCT-1160.480.2753.151.7429
Ovarian cancerA27800.480.2141.690.423
Prostate cancerPC30.340.0631.280.9327
DU1450.53N.a.20.96N.a.2
Breast cancerMCF70.510.141.04N.a.2
BT5491.870.3134.45N.a.2
MDA-MB2310.770.1742.161.4510
T47D0.510.1432.38N.a.2
Lung cancer (NSCL)NCI-H4601.290.2743.531.69
A5490.80.1141.620.397
Liver cancerHEP3B1.23N.a.22.131.16
PLC/PRF/50.90.183N.d.N.a.N.a.
Pancreas cancerMiaPaCa0.93N.a.22.870.486
Renal cancerACHN0.65N.a.22.45N.a.2
A4981.7N.a.24.25N.a.2
CAKI-11.59N.a.2N.d.N.a.N.a.
MelanomaMDA-MB4350.76N.a.21.851.0226
Thyroid cancerML-10.32N.a.2N.d.N.a.N.a.
TT26091.070.554N.d.N.a.N.a.
LeukemiaHL-600.070.0330.530.258
MV4-110.1N.a.20.220.166
HEL92.1.70.17N.a.20.310.085
MOLT-40.120.0630.53N.a.2
LymphomaMJ0.060.0230.470.283
H90.050.0240.160.074
HUT780.160.0850.580.235
RPMI82260.110.00130.310.13
L12360.290.114N.d.N.a.N.a.
Primary fibroblastsNHDF>100N.a.3N.d.N.a.N.a.

Abbreviation: NSCL, non–small cell lung; NHDF, normal human dermal fibroblast.

  • *Number of independent assays done; each assay was done in triplicates.

  • Not applicable.

  • Not done.