Table 1.

V1810 shows tolerable toxicity at effective concentrations

NaClVehicle solutionV1810 (10 mg/kg)V1810 (20 mg/kg)V1810 (30 mg/kg)
n on day 047788
n on day 547755
Body weight, day 0 (g)19.7 ± 0.919.9 ± 1.319.8 ± 2.019.9 ± 0.920.9 ± 1.2
Body weight, day 5 (g)19.2 ± 0.819.1 ± 1.120 ± 2.020.5 ± 0.320 ± 2.3
ALT/GPT (units/L)43 ± 1445 ± 1885 ± 4843 ± 1647 ± 15
AST/GOT (units/L)95 ± 26116 ± 66185 ± 12890 ± 22100 ± 30
AP (units/L)130 ± 19113 ± 2093 ± 893 ± 994 ± 21
Creatinine (mg/dL)<0.5<0.5<0.5<0.5<0.5
Bilirubine (mg/dL)<0.5<0.5<0.5<0.5<0.5
Hemoglobin15.9 ± 0.315.5 ± 0.014.4 ± 1.414.3 ± 0.414.8 ± 0.1
Urea87.5 ± 0.568.5 ± 8.552.0 ± 5.049.5 ± 2.566.0 ± 0.0
Spontaneous deaths00012
Killed for tail infection00021

NOTE: BalbC-mice were treated with i.v. injections of 10, 20, or 30 mg/kg V1810 daily. Control groups were treated with NaCl and vehicle solution (containing 10% DMSO and 20% cremophor RH40), respectively.

Abbreviations: ALT/GPT, alanine aminotransferase; AST/GOT, aspartate aminotransferase; AP, alkaline phosphatase.