Table 1.

Aurora kinase inhibitors in clinical trials

InhibitorAURKA inhibitionAURKB inhibitionAURKC inhibitionManufacturerClinical status
AZD1152++Astra ZenecaPhase I
VX-680+++Vertex/MerckDiscontinued
MLN8054++MillenniumDiscontinued
MLN8237++MillenniumPhase II
PHA-680632++NervianoPreclinical
PHA-739358+++NervianoPhase II
Hesperidin+Boehringer-IngelheimPreclinical
ZM447439++Astra ZenecaPhase I
JNJ-770621++Johnson & JohnsonPreclinical
SU6668++PfizerDiscontinued
CCT129202+++Chroma Therapeutics Ltd.Preclinical
AT9283++Astrex TherapeuticsPhase I
MP529++SuperGenPreclinical
SNS314+++Sunesis PharmaceuticalsPhase I
R763+Rigel PharmaceuticalsPhase I
ENMD2076++EntreMedPhase I
XL228+++ExelixisPhase I
TTP607+++TransTech PharmaPhase I
PF-03814735++PfizerPhase I
CYC116+++CyclacelPhase I

NOTE: Data source: http://www.clinicaltrial.gov.