Table 3.

Proteins that correlate with paclitaxel sensitivity

ProteinRPPA CategoryRPPA Versus −Log GI50 r ValueRPPA Versus −Log GI50 P valueGene SymbolsiRNA Average Viability (Paclitaxel)siRNA Average Deviation (Paclitaxel)siRNA Average Viability (Carrier)siRNA Average Deviation (Carrier)siRNA Ratio (Paclitaxel/Carrier)siRNA Paclitaxel Versus Carrier P value
CCND1Resistant−0.452<0.001CCND10.6510.0440.8390.0260.7760.023
TGM2Resistant−0.4110.001TGM20.6780.0070.7520.0160.9020.007
MVPResistant−0.3700.004MVP0.6880.0350.7830.0220.8780.0644
AP2M1Resistant−0.3490.007AP2M10.7660.0210.8720.0310.8780.052
CDH2Resistant−0.3450.007CDH20.6840.0280.7790.0160.8780.038
ANXA2Resistant−0.3440.008ANXA20.6690.0740.7600.0520.8810.261
KRT19Resistant−0.3280.011KRT190.6440.0210.6890.0440.9350.292
STAT1Resistant−0.3260.012STAT10.7610.0300.8770.0180.8680.016
TRADDResistant−0.2980.022TRADD0.8970.0321.0700.0600.8380.035
PGRResistant−0.2890.026PGR0.9350.0470.9310.0141.0040.931
JAK1Resistant−0.2650.042JAK11.0390.0371.1830.0300.8790.019
KRT18Resistant−0.2600.047KRT181.0420.0041.0250.0371.0170.698
STAT6Resistant−0.2600.046STAT60.7660.0240.8100.0340.9460.274
S6Sensitive0.280.032RPS60.8310.0080.7890.0271.0530.134
MYC;Sensitive0.2880.027MYC0.7100.0320.8140.0460.8730.086
MYCpT58Sensitive0.2960.023
P-MAPKSensitive0.3030.019MAPK10.8920.0250.9260.0120.9630.191
(P-MAPK)Sensitive0.3030.019MAPK30.8690.0390.8140.0231.0680.191
GSK3α/βSensitive0.3060.019GSK31.1160.0631.1400.0490.9790.714
(GSK3α/β)Sensitive0.3060.019GSK31.1520.0801.0990.0541.0480.531
P-JNKSensitive0.3090.017MAPK81.0790.0470.9860.0161.0950.078
SMN1Sensitive0.3180.014SMN10.5960.2870.8250.0420.7220.369
ADNPSensitive0.3230.013ADNP1.0810.0531.0530.0411.0270.627
P-P38Sensitive0.3250.012MAPK140.9140.0500.8860.0181.0320.518
MCM7Sensitive0.3510.006MCM70.8850.0160.9400.0290.9410.097
NME1Sensitive0.3640.005NME10.9580.0400.9490.0121.0100.800
MedianResistant−0.3280.0110.7610.0300.8390.0300.8790.052
MedianSensitive0.3060.0190.8920.0400.9260.0291.0100.191

NOTE: For antibodies that recognize more than one protein (i.e., GSK3αβ recognizes both GSK3α and GSK3β), the results for siRNA against each protein is presented. Both Total and Phospho MYC protein levels correlated with sensitivity to paclitaxel. For siRNAs that showed a significant difference (P < 0.05) for growth in the presence of paclitaxel as compared the carrier, the related proteins and P values presented in bold text.