Table 2.

Association study of mutation status with integrated RPPA data of NCI 60 cell lines

MutationTotalHomozygous
χ2P valueFisher's exact test P valueχ2P valueFisher's exact test P value
P530.9270150.9352140.5559240.575416
P160.4502160.4279480.2502270.230189
RB0.3436130.4412970.3533760.417028
PTEN*0.1359620.1090340.0593050.047797
PIK3CA0.1033160.198385NaN1
LKB10.3948280.5195350.7549970.913696
APC*0.0280540.0580230.2530530.634973
SMAD40.1029520.1733470.5924181
VHL0.6966820.8606560.6966820.860656
RAS0.2400450.3065940.6651840.808537
B-RAF*0.0060840.012280.0321720.039891
FLT30.2175840.283333NaN1
BRCA10.5924181NaN1
BRCA20.1029520.173347NaN1
HER20.2935370.636066NaN1
EGFR0.2935370.1196720.2175840.283333
PDGFR-a0.2175840.283333NaN1
B-CATENIN0.4515290.483333NaN1

NOTE: Five group χ2 test and Fisher's exact test of mutation status against RPPA-defined clusters were done.

  • *Mutations showing significant enrichment in specific clusters.