Table 2.

Droxinostat selectively inhibits HDAC3, HDAC6, and HDAC8

HDAC isoformDroxinostat IC50 (μmol/L)
1>20
2>20
316.9 ± 5.0
4>20
5>20
62.47 ± 1.09
7>20
81.46 ± 0.11
9>20
10>20

NOTE: Recombinant HDAC1 to HDAC10 were treated with increasing concentrations of droxinostat, and deacetylase activity was measured using a fluorescent assay as described in Materials and Methods. Data represent the mean and SD from two independent experiments (n = 4).