Table 1.

Drug activities across leukemia and central nervous system cell lines and summary statistics for complete NCI-60 cell-line screen

Cell LineFdUMP[10]5FUFUdRTopotecan HClIrinotecan HCl
NSC-697912NSC-19893NSC-27640NSC-609699NSC-616348
CNS:SF-2688.304.306.537.925.41
CNS:SF-2958.304.306.507.695.14
CNS:SF-5398.305.886.537.895.30
CNS:SNB196.773.945.917.664.62
CNS:SNB756.453.746.037.684.80
CNS:U2516.944.356.357.795.39
LE:CCRF-CEMna4.486.418.075.46
LE:HL-607.904.686.277.854.95
LE:K-5625.634.686.117.224.96
LE:MOLT-48.284.876.448.065.78
LE:RPMI-82266.645.315.746.614.69
LE:SR8.305.386.507.666.63
NCI-60 Minimum4.303.313.615.454.08
NCI-60 Maximum8.305.986.588.076.63
NCI-60 Average7.154.645.837.194.89
NCI-60 Range4.002.672.962.632.55

Note: Drug activities are GI50s, presented as −log10 values. Drug activities obtained from http://dtp.nci.nih.gov/dtpstandard/cancerscreeningdata/index.jsp.

Abbreviations: CNS, central nervous system; LE, leukemia; na, not applicable; NSC, National Service Center.