Table 1.

Effect of pioglitazone on vinyl carbamate–induced lung adenocarcinoma development

p53*TreatmentsnLung tumor multiplicity (average no. tumor per lung)Lung tumor load (sum of tumor volume per lung in average)
n ± SDt testLoad ± SDt testInhibition
+/+Gavage controlVehicle1041.7 ± 3.926.49 ± 10.43
+/+Pioglitazone15 mg/kg body weight, gavage1042.5 ± 6.9>0.059.55 ± 2.820.000563.9%
+/−Gavage controlVehicle949.7 ± 10.5>0.0571.66 ± 31.04P = 0.0002
+/−Pioglitazone15 mg/kg body weight, gavage1949.4 ± 8.7>0.0536.09 ± 17.230.006949.6%
  • *+/+, wt/wt; +/-, wt/Ala135Val.

  • Compared with the p53+/+ controls.