Table 2.

Dose-escalation scheme and DLT

BIBF 1120 dose (mg bid)No. of patientsDLTs
TotalDLT in first course
15030
200123ALT and γ-GT increase; ALT increase; AST, ALT, and γ-GT increase
25063AST and ALT increase; ALT increase; γ-GT increase

Abbreviations: bid, twice daily; γ-GT, γ–glutamyl transferase.