Dose-escalation scheme and DLT
| BIBF 1120 dose (mg bid) | No. of patients | DLTs | |
|---|---|---|---|
| Total | DLT in first course | ||
| 150 | 3 | 0 | |
| 200 | 12 | 3 | ALT and γ-GT increase; ALT increase; AST, ALT, and γ-GT increase |
| 250 | 6 | 3 | AST and ALT increase; ALT increase; γ-GT increase |
Abbreviations: bid, twice daily; γ-GT, γ–glutamyl transferase.