Table 1.

Summary of the pharmacokinetic parameters of RLI, IL-2, and IL-15 in male C57BL/6 mice following a single i.p. administration

RLIIL-2IL-15
Dose (μg)4482.5302.428.8
Dose (nmol)0.161.920.161.920.161.92
Cmax (ng/mL)1181,8103535047319
Tmax (h)120.510.51
T1/2 (h)330.170.420.50.5
AUC (ng/mL.h)87216,6382848475524

Abbreviations: Cmax, maximum plasma concentration; Tmax, time to reach maximum plasma concentration; T1/2, half-life.