Table 1.

Sensitivity of gastric cancer cell lines to AZD6244 and gefitinib

Cell linesKRASOthersGefitinib IC50(μmol/L)AZD6244 IC50 (μmol/L)
SNU1MT, G12D>100.262 ± 0.011
SNU601MT, G12D>100.068 ± 0.020
SNU668MT, Q61K>100.034 ± 0.002
AGSMT, G12DPIKCA, E453K*>100.992 ± 0.043
SNU484WT>101.370 ± 0.110
SNU719WT>100.141 ± 0.001
SNU5WTMET amplification>108.178 ± 1.056
SNU638WTMET amplification>103.277 ± 0.092
SNU16WTFGFR2 amplification>10>10

NOTE: Shown are the IC50 values of each drug using MTT assay, as described in the Methods on gastric cancer cell lines.

Abbreviation: MT, mutant.

  • *PIK3CA mutation status is referred to the Wellcome Trust Sanger Institute.