Table 1.

Apoptosis, proliferation, and microvessel density in tumors derived from MAT B III and MAT B III ETAR siRNA cells (means ± SD)

MAT B IIIMAT B III-ETAR siRNA
sl/sl (n = 17)sl/+ (n = 39)+/+ (n = 19)sl/sl (n = 4)sl/+ (n = 24)+/+ (n = 10)
TUNEL positivity (%)23.1 ± 8.7*23.0 ± 9.920.0 ± 8.748.4 ± 9.4*40.9 ± 11.942.6 ± 8.1
Ki67 positivity (%)22.8 ± 6.247.7 ± 13.353.3 ± 12.922.5 ± 5.924.6 ± 4.822.8 ± 7.1
Microvessel density (vessels/mm2)35.0 ± 1438.0 ± 1641.0 ± 22n.p.n.p.n.p.

Abbreviation: n.p., not performed.

  • *P values for all subgroups of MAT B III versus respective MAT B III-ETAR siRNA, <0.001.

  • P values for sl/sl versus sl/+ and +/+, <0.0001.