Table 2.

Phase I and phase II enzymes up-regulated in Cul3-silenced MCF-7 cells

Genebank accession no.Detoxifying enzymeFold increaseFunction
NM_014862Aryl-hydrocarbon receptor nuclear translocator 2 (ARNT2)3.69 ± 0.27Phase I
NM_000104Cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1)4.02 ± 0.45Phase I
NM_001353Aldo-keto reductase family 1, member C1 (AKR1C1)4.29 ± 0.791Phase II
NM_003774Udp-n-acetyl-α- d-galactosamine: polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)4.15 ± 0.97Phase II
NM_199127γ-Glutamyltransferase-like 4 (GGTL4)2.67 ± 0.50Phase II
NM_003312Thiosulfate sulfurtransferase (rhodanese; TST)2.08 ± 0.55Phase II
NM_003329Thioredoxin (TXN)1.63 ± 0.10Phase II
NM_003359UGDH7.70 ± 0.43Phase II