Phase I and phase II enzymes up-regulated in Cul3-silenced MCF-7 cells
| Genebank accession no. | Detoxifying enzyme | Fold increase | Function |
|---|---|---|---|
| NM_014862 | Aryl-hydrocarbon receptor nuclear translocator 2 (ARNT2) | 3.69 ± 0.27 | Phase I |
| NM_000104 | Cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) | 4.02 ± 0.45 | Phase I |
| NM_001353 | Aldo-keto reductase family 1, member C1 (AKR1C1) | 4.29 ± 0.791 | Phase II |
| NM_003774 | Udp-n-acetyl-α- d-galactosamine: polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) | 4.15 ± 0.97 | Phase II |
| NM_199127 | γ-Glutamyltransferase-like 4 (GGTL4) | 2.67 ± 0.50 | Phase II |
| NM_003312 | Thiosulfate sulfurtransferase (rhodanese; TST) | 2.08 ± 0.55 | Phase II |
| NM_003329 | Thioredoxin (TXN) | 1.63 ± 0.10 | Phase II |
| NM_003359 | UGDH | 7.70 ± 0.43 | Phase II |