GI50 values (pmol/L) of meayamycin against various human cancer cell lines
| MCF-7* | MDA-MB231† | HCT116‡ | PC-3§ | H1299∥ | A549¶ | DU-145** | HeLa†† |
|---|---|---|---|---|---|---|---|
| 20 ± 8.9 | 71 ± 55 | 157 ± 33 | 196 ± 42 | 841 ± 271 | 258 ± 162 | 1,234 ± 697 | 306 ± 175 |
NOTE: Data are the averages ± SD of at least three independent experiments (5-d assays for MCF-7 cells, and 3-d assays for other cells), each with quadruplicate determinations.
↵*Breast cancer cells, estrogen receptor–positive.
↵†Breast cancer cells, estrogen receptor–negative.
↵‡Colon carcinoma cells, wild-type p53.
↵§Colon carcinoma cells, p53-deficient.
↵∥Lung carcinoma cells, p53-deficient.
↵¶Lung carcinoma cells, wild-type p53.
↵**Prostate carcinoma cells.
↵††Cervical cancer cells.