Table 1.

GI50 values (pmol/L) of meayamycin against various human cancer cell lines

MCF-7*MDA-MB231HCT116PC-3§H1299A549DU-145**HeLa††
20 ± 8.971 ± 55157 ± 33196 ± 42841 ± 271258 ± 1621,234 ± 697306 ± 175

NOTE: Data are the averages ± SD of at least three independent experiments (5-d assays for MCF-7 cells, and 3-d assays for other cells), each with quadruplicate determinations.

  • *Breast cancer cells, estrogen receptor–positive.

  • Breast cancer cells, estrogen receptor–negative.

  • Colon carcinoma cells, wild-type p53.

  • §Colon carcinoma cells, p53-deficient.

  • Lung carcinoma cells, p53-deficient.

  • Lung carcinoma cells, wild-type p53.

  • **Prostate carcinoma cells.

  • ††Cervical cancer cells.