Table 1.

HBX 41,108 specificity on a panel of proteases

FamilyNameIC50 (╬╝mol/L)
Aspartic proteasesRenin>10
Cathepsin D>10
Cathepsin E>10
HIV-1 protease>10
Serine proteasesTrypsin>10
Factor Xa>10
Thrombin>10
Plasmin>10
Metallo proteasesACE>10
Cysteine proteasesCalpain-1>10
Cathepsin B>1
Cathepsin L>1
Cathepsin S>1
UCH-L1>1
SENP1>10
USP70.42