IC50 of NSCLC, mesothelioma, and SCLC lines to panobinostat
| Species | Cell line | Panobinostat | SAHA LD50 | ||
|---|---|---|---|---|---|
| IC50 (nmol/L) | LD50 (nmol/L) | ||||
| NSCLC | Human | H1299 | 5 | 120 | >25 μmol/L |
| Human | L55 | 11 | 80 | ||
| Human | A549 | 30 | 50 | ||
| Human | H460 | 40 | 90 | ||
| Human | H1264 | 100 | 250 | ||
| Human | H322 | 100 | 400 | ||
| Human | H661 | >800 | |||
| Mouse | TC1 | 20 | 75 | >800 nmol/L | |
| Mouse | LLC | 85 | 200 | ||
| Mouse | L1C2 | 90 | |||
| Mouse | LKR | 310 | 690 | ||
| MESO | Human | OK-6 | 5 | 5 | 12 μmol/L |
| Human | OK-5 | 7 | 7 | 1.5 μmol/L | |
| Human | LRK | <10 | 30 | >800 nmol/L | |
| Human | OK-4 | 25 | 60 | ||
| Human | M30 | 30 | 100 | ||
| Human | REN | 30 | |||
| Human | H513 | 35 | |||
| Human | OK-2 | 50 | 620 | 14 μmol/L | |
| Mouse | AB-1 | 20 | |||
| Mouse | AE17-ova | 25 | 80 | ||
| Mouse | AC29 | 40 | |||
| Mouse | AB12 | 470 | |||
| SCLC | Human | RG-1 | 4 | 6 | |
| Human | LD-T | 5 | 11 | ||
| Human | GLE | 8 | 8 | 800 nmol/L | |
| Human | H209 | 6 | 10 | ||
| Human | H209/CP | 8 | 20 | ||
| Human | BKT | 9 | 13 | ||
| Human | LVE | 9 | |||
| Human | TY-E | 10 | 19 | 3 μmol/L | |
| Human | H526 | 10 | 12 | ||
| Human | HG-E | 10 | 12 | ||
| Human | SH-A | 12 | |||
| Human | H69 | 20 | 25 | ||
| Human | ADA | 25 | |||
| Human | SM-E | 175 | |||
NOTE: Comparison of IC50 and LD50 of panobinostat for 37 lung cancer cell lines: 11 NSCLC cell lines (7 human, 4 mouse), 12 mesothelioma (MESO) cell lines (8 human, 4 mouse), and 14 SCLC cell lines (all human). Selected cell lines were compared with SAHA. Note that most of the IC50 values are in the low nmol/L range.