Table 1.

IC50 of NSCLC, mesothelioma, and SCLC lines to panobinostat

SpeciesCell linePanobinostatSAHA LD50
IC50 (nmol/L)LD50 (nmol/L)
NSCLCHumanH12995120>25 μmol/L
HumanL551180
HumanA5493050
HumanH4604090
HumanH1264100250
HumanH322100400
HumanH661>800
MouseTC12075>800 nmol/L
MouseLLC85200
MouseL1C290
MouseLKR310690
MESOHumanOK-65512 μmol/L
HumanOK-5771.5 μmol/L
HumanLRK<1030>800 nmol/L
HumanOK-42560
HumanM3030100
HumanREN30
HumanH51335
HumanOK-25062014 μmol/L
MouseAB-120
MouseAE17-ova2580
MouseAC2940
MouseAB12470
SCLCHumanRG-146
HumanLD-T511
HumanGLE88800 nmol/L
HumanH209610
HumanH209/CP820
HumanBKT913
HumanLVE9
HumanTY-E10193 μmol/L
HumanH5261012
HumanHG-E1012
HumanSH-A12
HumanH692025
HumanADA25
HumanSM-E175

NOTE: Comparison of IC50 and LD50 of panobinostat for 37 lung cancer cell lines: 11 NSCLC cell lines (7 human, 4 mouse), 12 mesothelioma (MESO) cell lines (8 human, 4 mouse), and 14 SCLC cell lines (all human). Selected cell lines were compared with SAHA. Note that most of the IC50 values are in the low nmol/L range.